International Journal of Infectious Diseases and Therapy

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Types of Tuberculosis and Factors Associated with Treatment Outcome and Mortality in the Obuasi Municipality of Ashanti Region, Ghana

Received: 4 September 2023    Accepted: 19 September 2023    Published: 8 October 2023
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Abstract

Introduction: Tuberculosis (TB) affects all persons in all countries of the world. Treatment outcomes remain a global indicator for measuring a country’s progress towards elimination of tuberculosis. Objective: The study was conducted to determine the distribution of TB by type and factors associated with treatment outcomes and mortality among a cohort of patients who received treatment for this disease between January 2015-December 2017 in the Obuasi municipality of Ghana. Results: The distribution of TB type were as follows: smear positive pulmonary TB (SPPTB), 50.0%, clinically diagnosed (smear negative) pulmonary TB 46.2%, extra-pulmonary TB 3.8% and 114 (19.83%) TB+HIV comorbidity. About 157 (27.30%) of TB patients were not screened for HIV. Successful treatment outcome rate was 77.20%. Unsuccessful treatment outcome rate was 22.80%; 7.90% defaulted, whereas 13.77% died, 0.90% treatment failure and 0.23% transferred out. In multivariable analysis, TB-HIV co-morbidity (aOR=3.37, 95% CI=1.50-7.57, p=0.003) was associated with unsuccessful treatment outcome and mortality (aOR=3.38, 95% CI=1.60-7.12, p=0.001). HIV infection reduced the likelihood of patient having successful treatment outcome whilst increasing the risk of mortality. Noncompliance with enhanced surveillance of screening all TB patients for HIV was common.

DOI 10.11648/j.ijidt.20230804.11
Published in International Journal of Infectious Diseases and Therapy (Volume 8, Issue 4, December 2023)
Page(s) 127-131
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Factors, Tuberculosis, Types, TB-HIV Co-morbidity, Treatment Outcomes, Mortality, Ghana

References
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[2] WHO. World Health Organization. Global Tuberculosis Program: Global tuberculosis control 20177. 2017; November 2017: 1–4.
[3] WHO. TB burden estimates, notifications and treatment outcomes. 2018.
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[5] CDC. Treatment for Latent TB Infection. New York: Center for Disease Prevention and Control; 2016.
[6] WHO. Global Tuberculosis Report. Geneva, Switzerland; 2018.
[7] Atif M, Sulaiman SAS, Shafie AA, Ali I, Asif M, Babar ZUD. Treatment outcome of new smear positive pulmonary tuberculosis patients in Penang, Malaysia. BMC Infect Dis. 2014.
[8] Dora C, Haines A, Balbus J, Fletcher E, Adair-Rohani H, Alabaster G, et al. Indicators linking health and sustainability in the post-2015 development agenda. The Lancet. 2014.
[9] Ghana Statistical Service (GSS). 2010 POPULATION & HOUSING CENSUS: Summary report of final results. Accra, Ghana; 2012.
[10] Ali MK, Karanja S, Karama M. Factors associated with tuberculosis treatment outcomes among tuberculosis patients attending tuberculosis treatment centres in 2016-2017 in Mogadishu, Somalia. Pan Afr Med J. 2017; 28.
[11] Melese A, Zeleke B. Factors associated with poor treatment outcome of tuberculosis in Debre Tabor, northwest Ethiopia. BMC Res Notes. 2018; 11.
[12] Guiastrennec B, Ramachandran G, Karlsson MO, Kumar AKH, Bhavani PK, Gangadevi NP, et al. Suboptimal Antituberculosis Drug Concentrations and Outcomes in Small and HIV-Coinfected Children in India: Recommendations for Dose Modifications. Clin Pharmacol Ther. 2018.
[13] WHO. Global Tuberculosis Report. Geneva, Switzerland; 2019.
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[16] Matambo R, Takarinda KC, Thekkur P, Sandy C, Mharakurwa S, Makoni T, et al. Treatment outcomes of multi drug resistant and rifampicin resistant Tuberculosis in Zimbabwe: A cohort analysis of patients initiated on treatment during 2010 to 2015. PLoS ONE. 2020.
[17] Babatunde OA, Elegbede OE, Ayodele M, Fadare JO, Isinjaye AO, Ibirongbe DO, et al. Factors Affecting Treatment Outcomes of Tuberculosis in a Tertiary Health Center in Southwestern Nigeria. Int Rev Soc Sci Humanit. 2013.
[18] Ohene SA, Bakker MI, Ojo J, Toonstra A, Awudi D, Klatser P. Extra-pulmonary tuberculosis: A retrospective study of patients in Accra, Ghana. PLoS One. 2019.
[19] Duru CB, Uwakwe KA, Nnebue CC, Diwe KC, Merenu IA, Emerole CO, et al. Tuberculosis Treatment Outcomes and Determinants among Patients Treated in Hospitals in Imo State, Nigeria. OALib. 2016; 03: 1–17.
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    Daniel Yeboah Asiamah, Georgina Frimpong Siraa, Obed Kumi, Williams Domechele, Philip Teg-Nefaah Tabong. (2023). Types of Tuberculosis and Factors Associated with Treatment Outcome and Mortality in the Obuasi Municipality of Ashanti Region, Ghana. International Journal of Infectious Diseases and Therapy, 8(4), 127-131. https://doi.org/10.11648/j.ijidt.20230804.11

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    ACS Style

    Daniel Yeboah Asiamah; Georgina Frimpong Siraa; Obed Kumi; Williams Domechele; Philip Teg-Nefaah Tabong. Types of Tuberculosis and Factors Associated with Treatment Outcome and Mortality in the Obuasi Municipality of Ashanti Region, Ghana. Int. J. Infect. Dis. Ther. 2023, 8(4), 127-131. doi: 10.11648/j.ijidt.20230804.11

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    AMA Style

    Daniel Yeboah Asiamah, Georgina Frimpong Siraa, Obed Kumi, Williams Domechele, Philip Teg-Nefaah Tabong. Types of Tuberculosis and Factors Associated with Treatment Outcome and Mortality in the Obuasi Municipality of Ashanti Region, Ghana. Int J Infect Dis Ther. 2023;8(4):127-131. doi: 10.11648/j.ijidt.20230804.11

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  • @article{10.11648/j.ijidt.20230804.11,
      author = {Daniel Yeboah Asiamah and Georgina Frimpong Siraa and Obed Kumi and Williams Domechele and Philip Teg-Nefaah Tabong},
      title = {Types of Tuberculosis and Factors Associated with Treatment Outcome and Mortality in the Obuasi Municipality of Ashanti Region, Ghana},
      journal = {International Journal of Infectious Diseases and Therapy},
      volume = {8},
      number = {4},
      pages = {127-131},
      doi = {10.11648/j.ijidt.20230804.11},
      url = {https://doi.org/10.11648/j.ijidt.20230804.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijidt.20230804.11},
      abstract = {Introduction: Tuberculosis (TB) affects all persons in all countries of the world. Treatment outcomes remain a global indicator for measuring a country’s progress towards elimination of tuberculosis. Objective: The study was conducted to determine the distribution of TB by type and factors associated with treatment outcomes and mortality among a cohort of patients who received treatment for this disease between January 2015-December 2017 in the Obuasi municipality of Ghana. Results: The distribution of TB type were as follows: smear positive pulmonary TB (SPPTB), 50.0%, clinically diagnosed (smear negative) pulmonary TB 46.2%, extra-pulmonary TB 3.8% and 114 (19.83%) TB+HIV comorbidity. About 157 (27.30%) of TB patients were not screened for HIV. Successful treatment outcome rate was 77.20%. Unsuccessful treatment outcome rate was 22.80%; 7.90% defaulted, whereas 13.77% died, 0.90% treatment failure and 0.23% transferred out. In multivariable analysis, TB-HIV co-morbidity (aOR=3.37, 95% CI=1.50-7.57, p=0.003) was associated with unsuccessful treatment outcome and mortality (aOR=3.38, 95% CI=1.60-7.12, p=0.001). HIV infection reduced the likelihood of patient having successful treatment outcome whilst increasing the risk of mortality. Noncompliance with enhanced surveillance of screening all TB patients for HIV was common.},
     year = {2023}
    }
    

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  • TY  - JOUR
    T1  - Types of Tuberculosis and Factors Associated with Treatment Outcome and Mortality in the Obuasi Municipality of Ashanti Region, Ghana
    AU  - Daniel Yeboah Asiamah
    AU  - Georgina Frimpong Siraa
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    JF  - International Journal of Infectious Diseases and Therapy
    JO  - International Journal of Infectious Diseases and Therapy
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    PB  - Science Publishing Group
    SN  - 2578-966X
    UR  - https://doi.org/10.11648/j.ijidt.20230804.11
    AB  - Introduction: Tuberculosis (TB) affects all persons in all countries of the world. Treatment outcomes remain a global indicator for measuring a country’s progress towards elimination of tuberculosis. Objective: The study was conducted to determine the distribution of TB by type and factors associated with treatment outcomes and mortality among a cohort of patients who received treatment for this disease between January 2015-December 2017 in the Obuasi municipality of Ghana. Results: The distribution of TB type were as follows: smear positive pulmonary TB (SPPTB), 50.0%, clinically diagnosed (smear negative) pulmonary TB 46.2%, extra-pulmonary TB 3.8% and 114 (19.83%) TB+HIV comorbidity. About 157 (27.30%) of TB patients were not screened for HIV. Successful treatment outcome rate was 77.20%. Unsuccessful treatment outcome rate was 22.80%; 7.90% defaulted, whereas 13.77% died, 0.90% treatment failure and 0.23% transferred out. In multivariable analysis, TB-HIV co-morbidity (aOR=3.37, 95% CI=1.50-7.57, p=0.003) was associated with unsuccessful treatment outcome and mortality (aOR=3.38, 95% CI=1.60-7.12, p=0.001). HIV infection reduced the likelihood of patient having successful treatment outcome whilst increasing the risk of mortality. Noncompliance with enhanced surveillance of screening all TB patients for HIV was common.
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Author Information
  • Department of Public Health, Faculty of Health and Allied Sciences, Catholic University College of Ghana, Sunyani, Ghana

  • Nutition Unit, District Health Directorate, Adansi Asokwa-Kumasi, Ghana

  • Fomena Health Centre, Kumasi, Ghana

  • Navrongo Health Research Centre, Ghana Health Service, Navrongo, Ghana

  • School of Public Health, College of Health Sciences, University of Ghana, Accra, Ghana

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