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The Intervening Effect of Preventive Use of Antibacterials During the Perioperative Period in Orthopedic Department

Received: 1 February 2021    Accepted: 19 February 2021    Published: 4 March 2021
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Abstract

Objective: To assess the effect of orthopedic perioperative antibiotic prophylaxis intervention by clinical pharmacist. Methods: 1467 hospitalized patients in department of orthopedics with perioperative records in eight months in 2019 were chosen. 597 surgical cases before intervention were sampled as the control group, and 870 surgical records were sampled as intervention group. Investigation and analysis were performed in orthopedic perioperative prophylactic antibiotics. Results: Compared with the control group, the intervention group showed increased rationalities and decreased irrationalities in perioperative antibiotic prophylaxis. The unreasonable external use of teicoplanin was significantly decreased, and the postoperative prophylaxis duration was significantly shortened. There were no significant difference in the timing of perioperative antibiotic prophylaxis between two groups. Conclusions: After interventions for the preventive use of antibacterial drugs in orthopedic perioperative period, the rational use of antibacterial drugs has been significantly improved, the irrational use of drugs has been improved, and the effect of drug treatment has been improved. However, there is still a gap between the rational use of antibacterial drugs. Further strengthen supervision and management.

Published in International Journal of Infectious Diseases and Therapy (Volume 6, Issue 1)
DOI 10.11648/j.ijidt.20210601.16
Page(s) 41-44
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Clinical Pharmacist, Intervention, Orthopedics Department, Perioperative Antibiotic Prophylaxis

References
[1] Prokuski L, Clyburn TA, Evans RP and Moucha CS. (2011). Prophylactic antibiotics in orthopaedic surgery. Instr Course Lect 60: 545-555.
[2] Zhiming R, Zhifen X and Yinna Z. (2017). The effect of interventional antimicrobial therapy on the prevention of infection and the level of inflammatory factors in orthopedics perioperative period. Journal of North Pharmacy 17: 149-150.
[3] Rodriguez-Pardo D. (2019). Antibiotic prophylaxis in orthopaedic surgery: Clinical practice guidelines or individualized prophylaxis? Enferm Infecc Microbiol Clin 37: 557-559.
[4] Di ZHANG, Cai-hong, Xiao-yu H and Xiao-ke D. (2015). Usage and analysis of antibacterial drug in orthopedics department during perioperative period. CHINA MODERN MEDICINE 22: 163-166.
[5] Schnabel MJ, Wagenlehner F and Schneidewind L. (2019). Perioperative antibiotic prophylaxis for stone therapy. Curr Opin Urol 29: 89-95.
[6] Xupei X. (2020). Analysis of Comprehensive Intervention Effect of Preventive Application of Antibiotics in Orthopedics Perioperative Period. Chinese Remedies & Clinics 20: 628-630.
[7] Caixia L, Songmei L and Ying Z. (2012). Effect of intervention by clinical pharmacists on unreasonable medication in orthopaedics department during perioperative period. Chin J Nosocomiol 22: 4109-4111.
[8] Tan TL, Shohat N, Rondon AJ, Foltz C, Goswami K, Ryan SP, Seyler TM and Parvizi J. (2019). Perioperative Antibiotic Prophylaxis in Total Joint Arthroplasty: A Single Dose Is as Effective as Multiple Doses. J Bone Joint Surg Am 101: 429-437.
[9] Jingrui P, Xiaofei X and Hanquan L. (2019). Analysis of Effects of Clinical Pharmacists’Intervention on Prophylactic Use of Antibiotics in Removal of Internal Fixation Device for Fracture During Perioperative Period. Evaluation and analysis of drug-use in hospitals of China 3: 375-380.
[10] Kuong EE, Ng FY, Yan CH, Fang CX and Chiu PK. (2009). Antibiotic prophylaxis after total joint replacements. Hong Kong Med J 15: 458-462.
[11] Stefansdottir A, Robertsson O, W-Dahl A, Kiernan S, Gustafson P and Lidgren L. (2009). Inadequate timing of prophylactic antibiotics in orthopedic surgery. We can do better. Acta Orthop 80: 633-638.
[12] Rizvi M, Bille B, Holtom P and Schnall SB. (2008). The role of prophylactic antibiotics in elective hand surgery. J Hand Surg Am 33: 413-420.
[13] Zhiming R, Zhifen X and Yinna Z. (2020). Effect of interventional antimicrobial therapy on prevention of infection and levels of inflammatory factors during perioperative period of orthopedics. Journal of North Pharmacy 17: 149-150.
[14] Jian C, Hui Z and Fuxin Z. (2019). Effect of perioperative antibiotics on prevention of infection and inflammatory cytokines in orthopedic patients. The Department of Oral Medicine Electronic Magazine (Electronic Edition) 6: 124.
[15] Bryson DJ, Morris DL, Shivji FS, Rollins KR, Snape S and Ollivere BJ. (2016). Antibiotic prophylaxis in orthopaedic surgery: difficult decisions in an era of evolving antibiotic resistance. Bone Joint J 98-B: 1014-1019.
Cite This Article
  • APA Style

    Hui Liu, Suishan Qiu, Qinai Zhu, Lianfang Xue. (2021). The Intervening Effect of Preventive Use of Antibacterials During the Perioperative Period in Orthopedic Department. International Journal of Infectious Diseases and Therapy, 6(1), 41-44. https://doi.org/10.11648/j.ijidt.20210601.16

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    ACS Style

    Hui Liu; Suishan Qiu; Qinai Zhu; Lianfang Xue. The Intervening Effect of Preventive Use of Antibacterials During the Perioperative Period in Orthopedic Department. Int. J. Infect. Dis. Ther. 2021, 6(1), 41-44. doi: 10.11648/j.ijidt.20210601.16

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    AMA Style

    Hui Liu, Suishan Qiu, Qinai Zhu, Lianfang Xue. The Intervening Effect of Preventive Use of Antibacterials During the Perioperative Period in Orthopedic Department. Int J Infect Dis Ther. 2021;6(1):41-44. doi: 10.11648/j.ijidt.20210601.16

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  • @article{10.11648/j.ijidt.20210601.16,
      author = {Hui Liu and Suishan Qiu and Qinai Zhu and Lianfang Xue},
      title = {The Intervening Effect of Preventive Use of Antibacterials During the Perioperative Period in Orthopedic Department},
      journal = {International Journal of Infectious Diseases and Therapy},
      volume = {6},
      number = {1},
      pages = {41-44},
      doi = {10.11648/j.ijidt.20210601.16},
      url = {https://doi.org/10.11648/j.ijidt.20210601.16},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijidt.20210601.16},
      abstract = {Objective: To assess the effect of orthopedic perioperative antibiotic prophylaxis intervention by clinical pharmacist. Methods: 1467 hospitalized patients in department of orthopedics with perioperative records in eight months in 2019 were chosen. 597 surgical cases before intervention were sampled as the control group, and 870 surgical records were sampled as intervention group. Investigation and analysis were performed in orthopedic perioperative prophylactic antibiotics. Results: Compared with the control group, the intervention group showed increased rationalities and decreased irrationalities in perioperative antibiotic prophylaxis. The unreasonable external use of teicoplanin was significantly decreased, and the postoperative prophylaxis duration was significantly shortened. There were no significant difference in the timing of perioperative antibiotic prophylaxis between two groups. Conclusions: After interventions for the preventive use of antibacterial drugs in orthopedic perioperative period, the rational use of antibacterial drugs has been significantly improved, the irrational use of drugs has been improved, and the effect of drug treatment has been improved. However, there is still a gap between the rational use of antibacterial drugs. Further strengthen supervision and management.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - The Intervening Effect of Preventive Use of Antibacterials During the Perioperative Period in Orthopedic Department
    AU  - Hui Liu
    AU  - Suishan Qiu
    AU  - Qinai Zhu
    AU  - Lianfang Xue
    Y1  - 2021/03/04
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ijidt.20210601.16
    DO  - 10.11648/j.ijidt.20210601.16
    T2  - International Journal of Infectious Diseases and Therapy
    JF  - International Journal of Infectious Diseases and Therapy
    JO  - International Journal of Infectious Diseases and Therapy
    SP  - 41
    EP  - 44
    PB  - Science Publishing Group
    SN  - 2578-966X
    UR  - https://doi.org/10.11648/j.ijidt.20210601.16
    AB  - Objective: To assess the effect of orthopedic perioperative antibiotic prophylaxis intervention by clinical pharmacist. Methods: 1467 hospitalized patients in department of orthopedics with perioperative records in eight months in 2019 were chosen. 597 surgical cases before intervention were sampled as the control group, and 870 surgical records were sampled as intervention group. Investigation and analysis were performed in orthopedic perioperative prophylactic antibiotics. Results: Compared with the control group, the intervention group showed increased rationalities and decreased irrationalities in perioperative antibiotic prophylaxis. The unreasonable external use of teicoplanin was significantly decreased, and the postoperative prophylaxis duration was significantly shortened. There were no significant difference in the timing of perioperative antibiotic prophylaxis between two groups. Conclusions: After interventions for the preventive use of antibacterial drugs in orthopedic perioperative period, the rational use of antibacterial drugs has been significantly improved, the irrational use of drugs has been improved, and the effect of drug treatment has been improved. However, there is still a gap between the rational use of antibacterial drugs. Further strengthen supervision and management.
    VL  - 6
    IS  - 1
    ER  - 

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Author Information
  • Department of Pharmacy, The First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Pharmacy, The First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Laboratory Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Pharmacy, The First Affiliated Hospital of Jinan University, Guangzhou, China

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